• Application in pharmaceutical drug development: screening for neuroactive effects
• Non-invasive neuronal network recording in vitro
• High data yield from 60 electrodes simultaneously
• Standardized, low variability cell culture
• Excellent intra- and inter-culture repeatability
• Automatic detection of network response to drugs even in absence of neurotoxicity
• Reliable and valid network IC₅₀ values comparing well with literature and in vivo results
• Detection of network-driven effects beyond single-cell properties
• Detection of synaptic and presynaptic effects inaccessible to single-cell patch-clamp
• Long-term monitoring of synaptic and intracellular effects (neurotransmitter reuptake inhibition, vesicle release)

Last modified 02/07/06 06:32                             Upward